Friday, October 18, 2013

The percentage of people infected with this bacteria is different in different parts of the world.


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Helicobacter pylori is in many ways a special bacteria. Was isolated from the stomach of people where the extremely acidic environment theoretically impossible conditions for microbial life, and in this attribute among the violators of the laws of nature. This is the first bacterium that has been shown to cause cancer and limfon, seizures for her discovery Marshall and Warren 2005th the Nobel Prize.
Humans are the main reservoir and source of H. pylori. It is supposed to be passed through fekooralnom, it is consuming food and water contaminated by feces. The infection can spread between family members. Colonization is a lifetime if they are not applicable antimicrobial treatment.
The percentage of people infected with this bacteria is different in different parts of the world. To infection with H. pylori is coming in early childhood in developing countries, and later in the developed countries. In developing countries, the percentage of colonized and infected with H. pylori is very high at 70-90% of adults, while in developed countries this percentage is lower and is around 40%. It has been shown that approximately 90-95% of patients with peptic twelfth Radial intestine and 50-85% of patients with gastric Ciro have H. pylori infection.
Colonization of H. pylori invariably leads to acute inflammation of the stomach lining (gastritis). Acute gastritis is associated with nausea, pain in the stomach, vomiting, decreased production of stomach acid stomach bloating and belching. Once infected persons have an unpleasant odor from the mouth. Symptoms of acute illness can last from several days to 2 weeks. Once it occurs, the infection can be present for several years or decades or even a lifetime, it is that goes into chronic infection. Chronic infection leads in ulcers (ulcers) and cancer of the stomach. Cure the infection to the wound ulcer and prevent its recurrence.
In some patients with chronic gastritis leads to epithelial proliferation. This 100-fold seizures increased risk of developing gastric cancer. The risk of cancer depends on the strain of H. pylori and the host response. Cancer commonly cause cagA positive strains in people who produce high levels of IL-1. H. pylori infection is also associated with the infiltration of lymphoid tissue in the gastric mucosa. In a small number of patients may experience MALT lymphoma.
The most reliable seizures method for the detection seizures of infection with H pylori is gastroscopic evaluation lining of the stomach, where a biopsy is performed and mucosal samples taken for microscopic examination, cultivation and urease test.
For diagnostics are used serological tests, which are much more comfortable for the patient, but they have limited value. The blood is seeking specific antibodies to H. pylori. The existence of antibodies does not mean active infection! Active infection must prove multiple serological examination, measuring the amount of antibody and determining class antibodies. To make sure that this is an active infection based on the detection of antibody, it is necessary to do a quantitative test. Qualitative rapid test, labeled as plus or minus does not mean much in the diagnosis! Based on this we can say that a person has never been used or been in contact with H pylori.
It can be anything: the absence of infection, prebolovanu infection, seizures chronic or acute infection. However, a quantity test shows titer (concentration) antibodies in serum bolsnika and is used to assess seizures the state of infection. Always examine the steam serum samples (two samples) taken at intervals of 15-21 days. Be sure to determine classes of immunoglobulins IgG, IgA and IgM) and follows the dynamic (moving) antibody. If eve fold rise titer antibodies that means that the infection is active! You need to take care. If the antibody titer decreases, it means that the infection is in the process of healing and the applied therapy was successful. As long as the low value of antibody, which do not significantly change in the individual samples, this means that the patient acquired immunity. This condition seizures does not require any treatment. Antibodies can be maintained in the patient's blood for years after izliječenjea.


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