Dermatologic DISEASES ASSOCIATED WITH INFECTION Helicobacter pylori by the Dermatologist Dr. Del Sorbo SALERNO - SCAFATI H. pylori WAS JUST 32 YEARS AGO THE ISOLATED 'helicobacter pylori from the greek hělixέλιξ = spiral; βακτήριον = stick; pylori = pylorus (pyloric valve of the stomach) is a spiral-shaped bacterium and gram negative isolated in 1982 from human gastric mucosa in Australia, by the pathologist Robin Warren hypertrophic cardiomyopathy and microbiologist John Barry James Marshall, who was awarded the Nobel Prize in 2005 for this great discovery. In the first publication helicobacter pilory is described hypertrophic cardiomyopathy as unidentified curved bacillus. In the following years is called before Gastric Campylobacter like organism (GCLO), then in 1984 and Campylobacter pilory only in 1989 at the Congress of Ulm, Helicobacter pylori. In 1994, the International Agency for Research on Cancer classifies H. pylori as a class I carcinogen, as associated with gastric adenocarcinoma. Helicobacter pylori INFECTION AND SKIN DISEASES
Some skin diseases are associated more frequently than others to infection by Helicobacter pylori. These include the burning mouth syndrome, lichen planus, some clinical variants of urticaria, atopic dermatitis, pustular rosacea, psoriasis, l 'nummular hypertrophic cardiomyopathy eczema, Behcet's disease and some forms of prurigo. Many times, by a phenomenon dermatological persistent, then you will discover through testing, infection with helicobacter pylori. Some skin diseases associated with Helicobacter pylori infection, may be linked to increased production of leukotrienes, PAF and histamine hypertrophic cardiomyopathy in the course hypertrophic cardiomyopathy of infection with helicobacter, as the body's attempt to neutralize the bacteria. Other proinflammatory and vasoactive substances (eg. Nα methyl histamine) hypertrophic cardiomyopathy are produced directly hypertrophic cardiomyopathy dall'helicobacter. Some skin diseases, especially if they appeared suddenly (eg. Pustular rosacea, hives, etc), can sometimes be associated with infection by Helicobacter pylori. When the research was positive urease, hypertrophic cardiomyopathy a targeted therapy should be initiated according to current guidelines, to eradicate the infection. In some cases, the dermatological phenomenon associated with infection by Helicobacter pylori, may persist for longer or shorter periods, even after a successful eradication of the infection. In case of infection with Helicobacter pylori, the bacterium is advisable to seek after completing therapy (to assess the success) and cohabiting. While being sensitive hypertrophic cardiomyopathy to most antibiotics, it is preferred to use for its eradication, a combined therapy, based on the association of various drugs (eg. Antibiotics, proton pump inhibitors, antihistamines, etc.) because of poor effectiveness, which would have a single drug in an acid environment such as the one in which lurks the helicobacter. To medication may sometimes be accompanied natural remedies (eg. N-acetylcysteine, herbal remedies, etc.) that can augment the activity hypertrophic cardiomyopathy of traditional antibiotics.
Some skin diseases such as urticaria (top) and rosacea (below), can sometimes be associated with an 'infection with helicobacter pylori Helicobacter pylori, DYSBIOSIS BOWEL DISEASES AND Dermatologic
L 'Helicobacter pylori infection, it can run in a completely asymptomatic and only rarely may be associated with gastric phenomena (eg. Chronic atrophic gastritis, peptic ulcer, maltoma, etc) or dermatologic (eg. Rosacea, chronic urticaria, etc), which allow the research and eradication by means of a targeted therapy. Under physiological conditions, there is an environment in the stomach acid so as to prevent the growth of bacteria. The Helicobacter pylori possesses enzymatic activities (eg. Urease) which allow to survive the low pH of the stomach and is able to swim through the gastric mucus, thanks to its flagella and to 'mucolytic action of its protease, and phospholipase mucinasi. The Helicobacter pylori is able to counteract the normal local defenses, thanks to important enzymes such as catalase and superoxide dismutase. The presence of bacteria in saliva and faeces, makes it possible hypertrophic cardiomyopathy to transmit oral, fecal and even gold (but not exclusively) through sexual contact. The helicobacter pylori, of which there are several genetically different strains, is about 5 microns long and has a single circular chromosome of approximately 1.6 million base pairs, which encodes approximately 1500 proteins. hypertrophic cardiomyopathy The enzyme urease is a dodecamer hypertrophic cardiomyopathy formed by 6 subunits urea and 6 subunit UreB and allows to convert urea into ammonia and carbon dioxide, raising the pH that surrounds the bacterium and creating in
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