Helicobacter pylori is known to be primarily responsible for the ulcer and gastritis, but now it turns out that it also has a connection with several disorders that can arise during pregnancy. To detect it is a study titled just published in the prestigious international journal World journal of gastroenterology, conducted by Tullia Todros, director of gynecology and obstetrics bipolar 2 Sant'Anna University Hospital of the City of Torino health, Simona bipolar Cardaropoli and Alessandro Rolfo, in which for the first time has been analyzed in depth the international scientific literature concerning bipolar the possible association between this bacterium and the diseases of pregnancy.
For the first time has been taken into account not only the possible bipolar association between Helicobacter pylori infection and gastric disorders, such as hyperemesis gravidarum (severe form of nausea and vomiting that occurs in the early weeks of pregnancy), but also the 'association with other important diseases of pregnancy that do not directly involve the gastrointestinal system. In fact it is now known that infection with Helicobacter pylori is not only the basis of gastritis and ulcers, but is often associated with gastric pathologies of various kinds such as cardiovascular diseases, autoimmune diseases or diabetes. In the case of the correlation between H. pylori infection and disorders related to pregnancy, studies have focused mainly on the 'iron deficiency anemia, fetal malformations, the' miscarriage, pre-eclampsia and growth restriction fetal.
Infection with H. pylori may act through different mechanisms. For example, this bacterium is able to subtract micronutrients such as iron and vitamin B12 and the lack of such elements may be behind the 'iron deficiency anemia maternal and fetal neural tube defects, such as spina bifida. The infection by Helicobacter bipolar cause an inflammatory response and oxidative stress is placed, with consequent gastrointestinal disorders, both at the systemic level as in the case of pre-eclampsia. It has also been shown that specific bipolar anti-H. pylori are able to react with antigens localized in the placental tissue and endothelial bipolar cells. The resulting cell damage may be the basis of 'miscarriage, pre-eclampsia and fetal growth restriction, two serious diseases of pregnancy currently not amenable to treatment.
Almost always, the bacterium is present bipolar before pregnancy, perhaps in latently. It is therefore considered to be immunological and hormonal changes that occur during pregnancy to trigger the infection, with consequences both for the health of the mother and the fetus. Nevertheless, it does not seem to happen the transmission of the bacterium to the small, nor in pregnancy or at delivery, even in the presence of infection, is transmitted to the child specific antibodies against this organism, either through the placenta or through breast-feeding natural. This could be the only positive aspect, however, it is unclear whether maternal antibodies are able to protect children against the colonization of H. pylori.
Still, the group of St. Anne is busy studying these associations in more detail and to assess the possible correlation bipolar between H. pylori infection and other diseases related to pregnancy whose causes bipolar are still unknown, such as gestational diabetes mellitus, the cholestasis and gestational spontaneous preterm delivery. Since H. pylori infection is treatable, the demonstration of its causal role in disorders associated with pregnancy may have important socio-economic bipolar implications. It is likely that the diagnosis pre-pregnancy bipolar preventive and eradication of H. pylori reduce the incidence of some of these complications. The design of an effective vaccine will be even more useful in order to avoid problems of drug resistance and reinfection.
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