Sweden Your browser does not support JavaScript!
The symptoms of appendicitis are often diffuse and therefore epi pen it can be difficult to diagnose. It may be possible to predict the course of the disease through a blood test and thus determine epi pen what type of treatment the patient needs. Reveals a thesis from the Sahlgrenska Academy.
- We do not know why we get appendicitis. There is medical evidence to suggest that the causes are different, since some patients of ruptured epi pen appendix while others have a milder course. The disease is unpredictable and in a third of cases typical symptoms. Therefore it would be better epi pen not to treat patients in the same way but each case is unique, says Anna Solberg, one of the researchers at Fibrinolyslaboratoriet at the Sahlgrenska Academy and specialist at the Department epi pen of Surgery at Sahlgrenska University Hospital.
To be on the safe side, patients often had to undergo an operation which found a non-inflamed appendicitis. In many cases it is possible that antibiotics or observation would have been enough and they would have avoided surgery. But 20 percent of patients are experiencing that the cecum deficiencies and then there is an increased risk of complications such as wound infection, abscess in the abdomen and adhesions which in turn can lead to bowel obstruction and new operations.
- I've epi pen been in this thesis mapped the presence of tissue-degrading enzymes, proteases, the tissue around the area where the appendix has perforated into the tissue surrounding. The tissue samples were taken at different stages of appendicitis in order to investigate whether the amount of proteases are correlated with the severity of the inflammation, says Anna Solberg.
The results showed an imbalance between proteases and a subject, TIMP-1, whose function is to inhibit tissue-degrading enzymes. This imbalance was found to be significant for how the tissue damage that can lead to perforation of the appendix. - It means that we have gained epi pen a greater understanding of the mechanisms behind the process that could lead to a ruptured appendix, says Anna Solberg.
In addition, it was found that the TIMP-1 reflected the degree of inflammation in the blood. By extension, there is the possibility that a blood test could measure the amount of TIMP-1 as part of the clinical diagnosis and thus determine the severity of the inflammation. However, Anna Solberg, more studies of TIMP-1 with repeated blood samples taken during the course epi pen of the disease.
- I aim to continue research in the area to see whether TIMP-1 could represent an inflammatory marker for the diagnosis and progression. It could lead to more targeted surgery, fewer complications, less hospitalization and improve the possibility of a more individual treatment where the risk of increased resistance to antibiotics should be considered.
FACTS APPENDICITIS Appendicitis or colloquially appendicitis is an acute inflammation epi pen of the cecal worm-like appendage. It is the most common cause of acute abdominal operation in Western countries epi pen and approximately 12,500 patients undergo surgery each year in Sweden. Typical symptoms are soreness right of the lower abdomen, nausea, occasional vomiting, and fever. epi pen It can be treated with both surgery and antibiotics alone. In addition, the inflammation heal by itself.
For more information contact: Specialist Anna Solberg, telephone 031-3434429, mobile phone 0708-329330, email: anna.solberg@surgery.gu.se Supervisor: Associate Professor Mari-Louise epi pen Ivarsson, telephone 0300 -565000, mobile phone 0703-955517, e-mail: Mari-Lois.Ivarsson@lthalland.se Peter Falk, MD, Fibrinolysis lab. phone 031-3434970, Email: peter.falk@surgery.gu.se
Thesis in medicine at the Sahlgrenska Academy, Institute of Clinical Sciences, Department of Surgery Thesis title: Extracellular matrix remodeling proteases in acute appendicitis and Their Impact on appendiceal perforation
Your Browser does not support inline frames or ice documents currently configured not to display inline frames.
The symptoms of appendicitis are often diffuse and therefore epi pen it can be difficult to diagnose. It may be possible to predict the course of the disease through a blood test and thus determine epi pen what type of treatment the patient needs. Reveals a thesis from the Sahlgrenska Academy.
- We do not know why we get appendicitis. There is medical evidence to suggest that the causes are different, since some patients of ruptured epi pen appendix while others have a milder course. The disease is unpredictable and in a third of cases typical symptoms. Therefore it would be better epi pen not to treat patients in the same way but each case is unique, says Anna Solberg, one of the researchers at Fibrinolyslaboratoriet at the Sahlgrenska Academy and specialist at the Department epi pen of Surgery at Sahlgrenska University Hospital.
To be on the safe side, patients often had to undergo an operation which found a non-inflamed appendicitis. In many cases it is possible that antibiotics or observation would have been enough and they would have avoided surgery. But 20 percent of patients are experiencing that the cecum deficiencies and then there is an increased risk of complications such as wound infection, abscess in the abdomen and adhesions which in turn can lead to bowel obstruction and new operations.
- I've epi pen been in this thesis mapped the presence of tissue-degrading enzymes, proteases, the tissue around the area where the appendix has perforated into the tissue surrounding. The tissue samples were taken at different stages of appendicitis in order to investigate whether the amount of proteases are correlated with the severity of the inflammation, says Anna Solberg.
The results showed an imbalance between proteases and a subject, TIMP-1, whose function is to inhibit tissue-degrading enzymes. This imbalance was found to be significant for how the tissue damage that can lead to perforation of the appendix. - It means that we have gained epi pen a greater understanding of the mechanisms behind the process that could lead to a ruptured appendix, says Anna Solberg.
In addition, it was found that the TIMP-1 reflected the degree of inflammation in the blood. By extension, there is the possibility that a blood test could measure the amount of TIMP-1 as part of the clinical diagnosis and thus determine the severity of the inflammation. However, Anna Solberg, more studies of TIMP-1 with repeated blood samples taken during the course epi pen of the disease.
- I aim to continue research in the area to see whether TIMP-1 could represent an inflammatory marker for the diagnosis and progression. It could lead to more targeted surgery, fewer complications, less hospitalization and improve the possibility of a more individual treatment where the risk of increased resistance to antibiotics should be considered.
FACTS APPENDICITIS Appendicitis or colloquially appendicitis is an acute inflammation epi pen of the cecal worm-like appendage. It is the most common cause of acute abdominal operation in Western countries epi pen and approximately 12,500 patients undergo surgery each year in Sweden. Typical symptoms are soreness right of the lower abdomen, nausea, occasional vomiting, and fever. epi pen It can be treated with both surgery and antibiotics alone. In addition, the inflammation heal by itself.
For more information contact: Specialist Anna Solberg, telephone 031-3434429, mobile phone 0708-329330, email: anna.solberg@surgery.gu.se Supervisor: Associate Professor Mari-Louise epi pen Ivarsson, telephone 0300 -565000, mobile phone 0703-955517, e-mail: Mari-Lois.Ivarsson@lthalland.se Peter Falk, MD, Fibrinolysis lab. phone 031-3434970, Email: peter.falk@surgery.gu.se
Thesis in medicine at the Sahlgrenska Academy, Institute of Clinical Sciences, Department of Surgery Thesis title: Extracellular matrix remodeling proteases in acute appendicitis and Their Impact on appendiceal perforation
Your Browser does not support inline frames or ice documents currently configured not to display inline frames.
No comments:
Post a Comment