Polymyalgia rheumatica is a chronic inflammatory condition of unknown etiology that primarily affec

Polymyalgia rheumatica is a chronic inflammatory condition of unknown etiology that primarily affects the elderly. Patients usually have pain and weakness hcg diet reviews in the scapular and pelvic girdles, with great physical limitation to the achievement of daily chores. Unfortunately, the corticosteroids hcg diet reviews represent the mainstay of treatment and are often kept for a long term. The recurrence of the inflammation, which are not uncommon, occurring more commonly with doses of prednisone <7.5 mg / day, with treatment interruption and when weaning steroid dosage is fast.
The accurate assessment of disease activity in polymyalgia rheumatica is very problematic because the inflammatory hcg diet reviews markers used (speed hemossedimentação- VHS and C reactivation PCR) are not specific to that function. These acute phase proteins may be elevated in many inflammatory, infectious and neoplastic diseases by. HSV, in particular, tends to increase with age and decreased renal function. Some patients may have normal values of ESR in the diagnosis of polymyalgia rheumatica and still others may attend without elevated ESR and CRP at the time of detection of recurrence.
Due to this difficulty in assessing the state of activity of polymyalgia rheumatica, there was a great interest in seeking a more reliable biomarker for the diagnosis of both disease activity and for measuring response to treatment. Thus, Irish researchers conducted a prospective study of 60 patients with polymyalgia rheumatica to evaluate the role of plasma fibrinogen as a possible biomarker. Of the patients enrolled, 25 had active, hcg diet reviews newly diagnosed, and 35 stable disease, presumably inactive disease. After 6 weeks of follow up, the authors found that plasma fibrinogen showed higher specificity and likelihood ratio of the ESR and CRP both as activity detection for confirmation of remission of disease. This superior accuracy of plasma fbrinogênio is important because it will help the rheumatologist in its overall assessment of the patient and also the safest and most appropriate hcg diet reviews management of corticosteroid therapy. This work was published in the March issue of the journal Rheumatology.
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